Overall (N = 283) | MSIMI Yes (N = 125) | MSIMI No (N =158) | ESIMI Yes (N = 93) | ESIMI No (N =174) | |
---|---|---|---|---|---|
Age (Mean/SD yrs) | 62.31(9.98) | 63.93(10.84) | 62.95(10.21) | 63.87(10.92) | 62.31(9.98) |
Race (% white) | 81.63 | 78.4 | 84.18 | 80.65 | 84.48 |
Gender (% female) | 17.67 | 22.4 | 13.92 | 20.43 | 16.09 |
BMI | 29.24(4.52) | 28.26(4.30) | 29.32(5.11) | 28.06(4.26) | 29.25(4.52) |
Living arrangement (% alone) | 15.55 | 21.8 | 11.4* | 15.05 | 13.79 |
Marital Status (% not married) | 73.5 | 66.4 | 79.11* | 76.34 | 75.29 |
CESD (%≥16) | 22.58 | 27.42 | 18.71 | 26.88 | 19.88 |
BDI (%≥10) | 34.4 | 40 | 29.94 | 41.94 | 30.64 |
Smoking (%) | |||||
Current | 14.13 | 16.8 | 12.03 | 15.05 | 12.64 |
Past | 54.42 | 50.4 | 57.59 | 51.61 | 56.9 |
Never | 31.45 | 32.8 | 30.38 | 33.33 | 30.46 |
Aspirin (%) | 96.09 | 95.97 | 96.18 | 97.85 | 95.35 |
ACEI (%) | 66.31 | 65.32 | 67.09 | 65.59 | 67.63 |
Angiotensin II (%) | 13.17 | 17.74 | 9.55* | 15.05 | 11.05 |
Calcium Channel Blockers (%) | 23.13 | 21.77 | 24.2 | 19.35 | 23.84 |
Other lipid lowering medications (%) | 27.84 | 22.13 | 32.45 | 26.67 | 26.95 |
Statin(%) | 91.79 | 95.12 | 89.17 | 91.3 | 91.28 |
Anti-platelet agents (%) | 43.26 | 50.81 | 38.61 | 45.16 | 40.46 |
Beta blocker (%) | 84.04 | 87.9 | 81.01 | 89.25 | 80.35 |
History of MI(%) | |||||
Yes | 43.46 | 47.2 | 40.51 | 37.63 | 47.13 |
No | 55.48 | 51.2 | 58.86 | 60.22 | 52.3 |
NS | 1.06 | 1.6 | 0.63 | 2.15 | 0.57 |
PTCA (%) | 63.6 | 63.2 | 63.92 | 60.22 | 65.52 |
CABG (%) | 42.4 | 47.2 | 38.61 | 51.61 | 36.78* |
Diabetes Mellitus (%) | 72.08 | 69.6 | 74.05 | 69.89 | 73.56 |
Hyperlipidemia (%) | 93.99 | 94.4 | 93.67 | 92.47 | 94.83 |
Hypertension (%) | 81.27 | 80 | 82.28 | 78.49 | 82.76 |
NYHA Class (%) | |||||
1 | 91.13 | 91.94 | 90.51 | 91.4 | 91.38 |
2 | 6.74 | 6.45 | 6.96 | 7.53 | 5.75 |
3 | 1.77 | 1.61 | 1.9 | 1.08 | 2.3 |
LVEF(Mean/SD) | 56.74(10.32) | 55.22(11.66) | 57.94(10.98)* | 56.54(10.93) | 56.78(10.30) |
WMSI (Mean/SD) | 1.20(.37) | 1.28(.42) | 1.13(.32)* | 1.19(.36) | 1.20(.38) |
BDI-TOT | CESD | |||
---|---|---|---|---|
r | p | r | p | |
Age | -.16 | .009 | -.17 | .006 |
Gender | -.18 | .003 | -.25 | <.001 |
Resting LVEF | -.13 | .033 | -.07 | .262 |
Resting WMSI | .15 | .013 | .08 | .180 |
Exercise Duration | -.21 | <.001 | -.17 | .006 |
Peak HR | -.05 | .462 | -.05 | .448 |
Target HR | -.05 | .458 | -.12 | .052 |
MSIMI | MSIMI (adjusted) | |||||
---|---|---|---|---|---|---|
OR | p | C-index | OR | p | C-index | |
BDI-TOT | 1.30 (1.06 – 1.60) | .013 | .58 | 1.24 (1.00 - 1.54) | .053 | .66 |
BDI-SA | 1.29(1.06 – 1.57) | .012 | .59 | 1.21(0.98 - 1.48) | .071 | .66 |
BDI-CA | 1.36 (.81 – 2.28) | .24 | .54 | 1.41(.80 – 2.48) | .23 | .65 |
CESD-TOT | 1.31(.92 – 1.87) | .13 | .55 | 1.22(.83 – 1.78) | .32 | .65 |
CESD-PE | .68(.44 – 1.04) | .077 | .57 | .71(.45 – 1.12) | .14 | .66 |
CESD-NA | 1.36 (.95 – 1.95) | .091 | .54 | 1.33 (.90 – 1.98) | .16 | .65 |
CESD-Som | 1.21 (.84 – 1.75) | .30 | .53 | 1.07 (.73 – 1.58) | .72 | .64 |
CESD-IP | .97 (.70 – 1.35) | .85 | .50 | 1.02 (.72 – 1.43) | .92 | .64 |
Hostility | 1.07 (.80 – 1.43) | .64 | .52 | 1.05 (.77 – 1.42) | .77 | .64 |
Trait anxiety | 1.11 (.78 – 1.57) | .58 | .52 | 1.09 (.74 – 1.59) | .67 | .64 |
State anxiety | 1.19 (.81 – 1.74) | .38 | .52 | 1.21 (.80 – 1.82) | .36 | .66 |
PSS | 1.14 (.79 – 1.65) | .48 | .53 | 1.14 (.76 – 1.72) | .53 | .65 |
ESIMI | ESIMI (adjusted) | |||||
---|---|---|---|---|---|---|
OR | p | C-index | OR | p | C-index | |
BDI-TOT | 1.29 (1.03 - 1.62) | .025 | .60 | 1.33 (1.05 - 1.68) | .019 | .62 |
BDI-SA | 1.30(1.05 - 1.87) | .018 | .60 | 1.32(1.05 - 1.66) | .016 | .62 |
BDI-CA | 1.79(1.02 – 3.13) | .042 | .58 | 2.07(1.13 – 3.78) | .018 | .61 |
CESD-TOT | 1.36(.93 – 1.98) | .12 | .55 | 1.38(.92 – 2.07) | .12 | .58 |
CESD-PE | .57(.36 - .91) | .018 | .59 | .56(.35 - .90) | .017 | .59 |
CESD-NA | 1.35 (.92 – 1.98) | .13 | .56 | 1.41 (.93 – 2.15) | .11 | .59 |
CESD-Som | 1.08 (.73 – 1.60) | .70 | .51 | 1.06 (.71 – 1.59) | .78 | .55 |
CESD-IP | 1.18 (.83 – 1.67) | .37 | .53 | 1.21 (.84 – 1.72) | .31 | .56 |
Hostility | 92 (.68 – 1.25) | .60 | .52 | .95 (.69 – 1.31) | .75 | .55 |
Trait anxiety | 1.32 (.91 – 1.92) | .15 | .55 | 1.40 (.94 – 2.08) | .10 | .59 |
State anxiety | 1.45 (.97 – 2.17) | .074 | .56 | 1.50 (.98 – 2.28) | .060 | .59 |
PSS | 1.46 (.97 – 2.18) | .068 | .57 | 1.58 (1.01 – 2.47) | .045 | .60 |
REMIT | Responses of Myocardial Ischemia to Escitalopram Treatment |
CHD | Coronary Heart Disease |
MSIMI | Mental Stress Induced Myocardial Ischemia |
ESIMI | Exercise Induced Myocardial Ischemia |
CABG | Coronary artery bypass graft surgery |
PCI | Percutaneous coronary intervention |
ECG | Electrocardiography |
WMSI | Wall Motion Score Index |
LVEF | Left Ventricular Ejection Fraction |
BDI-CA | Beck Depression Inventory Cognitive Affective Score |
BDI-SA | Beck Depression Inventory Somatic Affective Score |
BDI-TOT | Beck Depression Inventory Total Score |
BDI-SA | Beck Depression Inventory Somatic Affective Score |
CESD-IP | Center for Epidemiologic Studies Depression Scale Interpersonal Problems Score |
CESD-NA | Center for Epidemiologic Studies Depression Scale Negative Affect Score |
CESD-PE | Center for Epidemiologic Studies Depression Scale Positive Emotions Score |
CESD-SOM | Center for Epidemiologic Studies Depression Scale Somatic Symptoms Score |
CESD-TOT | Center for Epidemiologic Studies Depression Scale Total Score |
CMHS | Cook-Medley Hostility Scale |
PSS | Perceived Stress Scale |
SSA | Spielberger State Anxiety Scale |
STA | Spielberger Trait Anxiety Scale |
OR | Odds Ratio |